Plasma fluphenazine levels by radioimmunoassay in schizophrenic patients treated with depot injections of fluphenazine decanoate.

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Quantitation of fluphenazine in equine serum following fluphenazine decanoate administration.

Fluphenazine, a potent antipsychotic used to treat schizophrenia in humans, is used in racehorses as a performance-enhancing drug, and for that reason it has been banned by the Association of Racing Commissioners International. A liquid chromatography-tandem mass spectrometry method for detecting and quantitating fluphenazine in equine serum was developed and validated. The method was then empl...

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Fluphenazine Decanoate in Chronic Schizophrenia

Introduction of chlorpromazine by Delay and Danikcr in 1952 revolutionized the treatment of acute schizophrenia. However, chronic form of the illness still remains a challenge, mainly because of noncompliance of the patients with the therapeutic regimen (Diamond and Marks, 1960; Olson and Peterson, 1960; Hare and Willcox, 1967 ; Wilson and Enoch, 1967 and Ayd, 1975). Another factor is the errat...

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The use of fluphenazine decanoate (Modecate)depot therapy in outpatient schizophrenics-a retrospective study.

One hundred and twenty seven outpatient schizophrenics treated with fluphenazine decanoate (Modecate) depot therapy for a minimal period of 24 months were selected from all the psychiatric outpatient clinics in Singapore. Using a mirror image analysis in which patients act as their own controls, 105 patients showed a significant reduction of relapses requiring admissions from 139 before the ins...

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Comparative Efficacy of Every 2 Weeks versus Every 6 Weeks Injections of Fluphenazine Decanoate

Background: Maintenance treatment of schizophrenia reduces relapse rates of this disease. This treatment is carried out for long periods of time and occasionally for lifelong. Dose reduction strategies are designed to maintain the benefits of antipsychotic drug therapy, while reducing the side effects. The authors tested a new dose reduction approach by increasing the interval between administr...

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Comparative effectiveness of fluphenazine decanoate injections every 2 weeks versus every 6 weeks.

OBJECTIVE Dose reduction strategies for the maintenance treatment of schizophrenia are designed to maintain the benefits of antipsychotic drug therapy while reducing risks. Previous strategies with decanoate preparations have been based on the use of lower doses per injection to achieve dose reduction; these strategies have achieved dose reduction but have resulted in some increase in symptoms....

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ژورنال

عنوان ژورنال: British Journal of Clinical Pharmacology

سال: 1979

ISSN: 0306-5251

DOI: 10.1111/j.1365-2125.1979.tb01045.x